GENE EXPRESSION SIGNATURES in cancer

P. K. Suresh  (Chennai Dental Research Foundation,  Chennai,  India)

2007•  Pages: 126. Size: 180x240•  Binding: Hard•  Price: US $ 35/-Rs. 850/-

(Special Issue of International Journal of Human Genetics - No. 8)

The present Special Issue with  collection of nine papers should enable the researcher/student and the clinician in better appreciating the importance of the GENE EXPRESSION SIGNATURES (GES), which can potentially improve diagnosis and/or prognosis. Cancer is a multi-factorial disease and hence, the approach has been to identify biomarkers in the continuum between the onset and disease progression. Collaborations (for e.g., multi-centric projects), in India as well as globally, that will synergize the efforts of clinicians, epidemiologists, scientists (wet-lab and social), computational biologists and bio-informaticians will improve our ability for inter-laboratory comparison of data. Cost-effective methods without compromising on the sensitivity, specificity, reproducibility, robustness, scalability, with ease of operation would be especially relevant in translating research ideas from the bench-side to the chair-side/bedside.

CONTENTS

Preface

Kunal Bhattacharya, Gerrit Alink and Elke Dopp • Oxidative Stress and Changed Gene Expression Profiles in Fiber-/Particle-Induced Carcinogenesis

B. Joseph and G. Kumaramanickavel  • ‘Insight’ into Molecular Genetic Testing in Retinoblastoma

R. Rajaraman, D. L. Guernsey, M.M. Rajaraman and S.R. Rajaraman • Neosis - A Parasexual Somatic Reduction Division in Cancer

Ramanathan S. Uma and T. Rajkumar • DNA  Microarray  and  Breast  Cancer-A  Review

Ranju Ralhan • Diagnostic Potential of Genomic and Proteomic Signatures in Oral Cancer

Rachna Pandey, Nitin Patil and Mala Rao • Proteases and Protease Inhibitors: Implications in Antitumorigenesis and Drug Development

Geeta K. Vemuganti and Chitra Kannabiran • Gene Expression Signatures in Stem Cells - Lessons for Therapy

Rukmini B Govekar and Surekha M Zingde • Cancer Proteomics: How Far are We from the Clinics?

P.K. Suresh, K. Ranganathan, S. Balasundaram and R. Gunaseelan  • Gene Expression Signatures – Ex Vivo / In Vitro Approaches for Signature Development and Validation

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