Educational Publishers since 1933

BOOKS

HUMAN GENETICS

GENETIC TOXICOLOGY

G. TALUKDER AND MADHUSNATA DE (Vivekananda Institute of

Medical Sciences, Kolkata, India) 2004• Pages: 100. Size: 180x240•

Binding: Hard• PRICE: US $ 35/-RS. 850/-

(Special Issue of International Journal of Human Genetics - 5)

GENETIC TOXICOLOGY

In any industry, the workers and the people living nearby are exposed to chemicals and gases, which are being used or discharged as effluents. Some, if not most of these, are capable of causing mutations or of causing changes in the genes of exposed populations. Such changes in the genes of an exposed person may lead to sterility and cancer and to inherited defects in the next generation. While there are many available tests for identifying overt toxic effects on human beings like allergy, irritation, infections etc., very few tests are available for measuring the genotoxic effects. This is because the knowledge about genotoxic effects is relatively vague and also because man has a rather longer life span than experimental animals and the alterations found can not be directly related to the cause. Genotoxic effects have been reported by many work place chemicals, like effluents and chemicals from industries manufacturing shoe, tyre, paints, varnish, steel, pottery, ceramics, dyes, pesticides, detergents and in tin plating, mining, road repairs etc. The incidence of cancer, sterility, foetal loss and immunodeficiency are only a few conditions, which are considerably increased due to genotoxic hazards. It is hoped that topics discussed in this special issue by various experts in the field would be useful to its readers.

CONTENTS

Preface

H.N. BANERJEE, M. VERMA AND S.K. DUTTA • 2-Am,4,6-DNT Causes Genotoxicity of P53 Gene in NG108 Neuroblastoma Cell Lines
R. J. VERMA • Aflatoxin Cause DNA Damage
SREEDEVI BALAKRIHNAN AND B. S. RAO • Cytogenetic Effects of Tritiated Water (HTO) In Human Blood Lymphocytes in vitro
K. B. ANJARIA AND B. S. RAO • Effect of Tumour Promoter Anthralin on Gamma Radiation and 4-nitroquinoline 1-oxide Induced Genotoxicity in Diploid Yeast
K.K. VIJAYALAXMI AND MARIE PREM D’SOUZA • Studies on the Genotoxic Effects of Anticancer Drug Carboplatin in in vivo Mouse
A. HALDER, T. CHAKRABORTY, K. MANDAL, P. K. GURE, S. DAS, R. RAYCHOWDHURY, A. K. GHOSH AND M. DE • Comparative Study of Exfoliated Oral Mucosal Cell Micronuclei Frequency in Normal, Precancerous and Malignant Epithelium
SANDEEP PODDAR, GEETA TALUKDER AND ARCHANA SHARMA • Chromosome Damage Induced by Ferric Chloride in Human Peripheral Lymphocytes
YOGESHWER SHUKLA AND SANJOY KUMAR PAL • Dietary Cancer Chemoprevention: An Overview
APARAJITA DAS AND ANITA MUKHERJEE • Genotoxicity Testing of the Food Colours Amaranth and Tartrazine
SUPRIYO DE, SAROJ K. PRAMANIK, ARTHUR L. WILLIAMS AND SISIR K. DUTTA • Toxicity of Polychlorobiphenyls and its Bioremediation

Index

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